Blood Coagulation, in Normal and Hypercholesterolemic Dogs, Unmodified by Chylomicrons*

L. A Kelly; H. A. I Newman

doi:10.1055/s-0038-1654883

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1965; 14(03/04): 466-472
DOI: 10.1055/s-0038-1654883

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Blood Coagulation, in Normal and Hypercholesterolemic Dogs, Unmodified by Chylomicrons*

L. A Kelly^**

¹Department of Physiology and Biophysics University of Tennessee Memphis, Tennessee (U.S.A.)

,

H. A. I Newman

¹Department of Physiology and Biophysics University of Tennessee Memphis, Tennessee (U.S.A.)

› Author Affiliations

Abstract

Summary

Investigations were performed on the effects of chylomicrons on blood coagulation. No clotting occurred when dog thoracic duct chylomicrons were substituted for the platelets used in the measurement of thromboplastin generation time.

Hypercholesterolemic or normal dog serum was incubated for 3 hours with chylomicrons to transfer 40% of the chylomicron phospholipids to serum lipoproteins. These sera also did not decrease thromboplastin generation time.

Thromboplastin generation of plasma and whole blood clotting times of dogs on high fat diets were not different than normal controls.

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References

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